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✱ Metabolic Health · 8 min read

How GLP-1 and GIP Receptors Influence Metabolism

A plain-language look at the incretin hormones behind today's most discussed metabolic medicines.

CelebrityRx Editorial Team ·

Incretin hormones

GLP-1 and GIP are hormones released from the gut after eating. They prompt the pancreas to release insulin when glucose is elevated.

Appetite and satiety

GLP-1 receptor activation slows gastric emptying and signals fullness to the brain, reducing food intake.

Approved medicines

Several GLP-1 receptor agonists, and the dual GIP/GLP-1 agonist tirzepatide, are FDA-approved for specific indications. Each carries specific warnings and requires a prescription.

Sources

  1. Jastreboff AM et al. Tirzepatide once weekly for the treatment of obesity. N Engl J Med. 2022.
  2. Drugs@FDA database

This article is for general education and is not medical advice. Talk to a qualified healthcare professional before starting, stopping or changing any treatment.