SS-31Illustrative mockup✱ Cellular Research · Mitochondrial Science
SS-31
A mitochondria-targeting peptide (elamipretide) studied for its interaction with the inner mitochondrial membrane.
Code
2S10
Per vial
$119.00
Kit (10 vials)
$1,190.00
Quote and order requests are disabled for this listing because it has no lawful consumer treatment pathway.
Research information only · not approved for use. A branded elamipretide product received FDA accelerated approval in 2025 for a specific rare mitochondrial disease (Barth syndrome); verify current labeling at fda.gov. The research vial listed here is not that product and is not approved for any use. Educational information only — quote requests are disabled.
✱ Overview
What is SS-31?
SS-31, also known as elamipretide, is a small synthetic peptide designed to concentrate in mitochondria. It binds cardiolipin, a lipid in the inner mitochondrial membrane that helps organize the machinery of energy production.
It has been studied in several clinical programs, including primary mitochondrial myopathy, Barth syndrome and heart failure, with mixed results across indications.
✱ Mechanism
How it works
Cardiolipin anchors and stabilizes the protein complexes of the electron transport chain. When cardiolipin is damaged by oxidative stress, energy production becomes less efficient and more reactive oxygen species are generated.
By associating with cardiolipin, SS-31 is proposed to stabilize membrane structure, improve electron transport efficiency and reduce oxidative stress at its source.
✱ Key research areas
What the science says — and how sure it is.
01
Mitochondrial disease (Barth syndrome)
Established clinical evidence
Clinical data supported FDA accelerated approval of a branded elamipretide product for Barth syndrome in 2025. Continued approval may depend on confirmatory evidence.
02
Mitochondrial membranes
Preliminary findings
Laboratory work consistently shows SS-31 binding cardiolipin and stabilizing inner-membrane structure.
03
Oxidative stress
Preliminary findings
Cell and animal studies show reduced mitochondrial reactive oxygen species.
04
Muscle function
Preliminary findings
A phase 3 trial in primary mitochondrial myopathy did not meet its primary endpoint.
05
Investigational applications
Experimental hypothesis
Heart failure, kidney and age-related muscle research remain investigational.
✱ Available specifications
Catalog reference
| Code | Specification | Vials / kit | Ref. price / vial | Kit total (calc.) |
|---|---|---|---|---|
| 2S10 | 10 mg/vial | 10 | $119.00 | $1,190.00 |
Prices are editable, illustrative per-vial references — not verified supplier costs or selling prices. Kit total = per-vial price × vials per kit. For this listing, prices are internal catalog references only, not consumer offers.
✱ Inquiry process
What happens next
01
Learn
Read the science and regulatory status above.
02
Ask
Send a general research-information inquiry.
03
Talk to a clinician
Ask a licensed professional about approved alternatives or clinical trials.
✱ Evidence & safety
Read before you ask.
Evidence quality: Moderate for one rare-disease indication of a branded product; investigational elsewhere.
Regulatory status: Research information only · not approved for use
Known safety concerns
- Injection-site reactions were the most common effect in trials
- Headache and dizziness reported
- Unknown purity and identity of research-grade material
Contraindications & cautions
- Not for self-administration
- Not approved for cognitive impairment, osteoarthritis, diabetes, glaucoma or cardiovascular disease
This information is educational and incomplete. Always seek advice from a qualified medical professional.
✱ FAQ
SS-31 questions
A specific branded elamipretide product was granted accelerated approval for Barth syndrome. The research vial listed here is not that product and is not approved.
No. Because this listing is not an approved treatment, quote requests are disabled. You can submit a general research-information inquiry.
It binds cardiolipin in the inner mitochondrial membrane, which researchers believe helps stabilize energy production.
✱ Research information
Have a question about SS-31?
This is a general information inquiry. It does not request purchase, treatment or a prescription.
✱ Related
You may also want to read about
NAD+✱ Energy & Recovery
NAD+
A coenzyme found in every living cell, central to energy metabolism and cellular maintenance.
Glutathione✱ Antioxidant
Glutathione
The body's master endogenous antioxidant, central to cellular redox balance.
Epithalon✱ Longevity Research
Epithalon
An experimental tetrapeptide investigated in aging-related and circadian-rhythm research.